2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140047
    Propargyl-PEG4-sulfonic acid 1817735-29-7 98.0%
    Propargyl-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-sulfonic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-sulfonic acid
  • HY-134714
    DBCO-PEG3-amine 2093409-57-3 99.99%
    DBCO-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG3-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG3-amine
  • HY-140753
    DOTA-(t-butyl)3-PEG5-azide 99.69%
    DOTA-(t-butyl)3-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DOTA-(t-butyl)3-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    DOTA-(t-butyl)3-PEG5-azide
  • HY-130454
    Mal-PEG6-PFP ester 1599486-33-5
    Mal-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG6-PFP ester
  • HY-140527
    1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane 35638-19-8
    1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane
  • HY-140685
    m-PEG20000-azide 98.0%
    m-PEG20000-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG20000-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG20000-azide
  • HY-140926
    N-(Propargyl-PEG4)-biocytin 2055042-71-0 98.0%
    N-(Propargyl-PEG4)-biocytin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Propargyl-PEG4)-biocytin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-(Propargyl-PEG4)-biocytin
  • HY-130584
    Propargyl-PEG2-MS 943726-01-0
    Propargyl-PEG2-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG2-MS is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-MS
  • HY-130557
    endo-BCN-PEG2-acid 1993134-72-7
    endo-BCN-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. endo-BCN-PEG2-acid is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG2-acid
  • HY-130150
    m-PEG5-succinimidyl carbonate 1058691-00-1 98.0%
    m-PEG5-succinimidyl carbonate is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-succinimidyl carbonate is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG5-succinimidyl carbonate
  • HY-141379
    N-Bromoacetyl-β-alanine 89520-11-6
    N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    N-Bromoacetyl-β-alanine
  • HY-140047A
    Propargyl-PEG4-sulfonic acid sodium
    Propargyl-PEG4-sulfonic acid sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-sulfonic acid sodium is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-sulfonic acid sodium
  • HY-141225
    m-PEG24-alcohol 2376450-73-4 99.74%
    m-PEG24-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG24-alcohol
  • HY-130882
    HS-PEG7-CH2CH2N3 2148986-06-3
    HS-PEG7-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. HS-PEG7-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    HS-PEG7-CH2CH2N3
  • HY-140808
    Azido-PEG3-C3-OH 1807512-36-2 98.0%
    Azido-PEG3-C3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-C3-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-C3-OH
  • HY-143830
    t-Boc-N-amido-PEG2-C6-Cl 920264-35-3 99.21%
    t-Boc-N-amido-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-N-amido-PEG2-C6-Cl
  • HY-140773
    Azido-PEG8-PFP ester 2055014-62-3
    Azido-PEG8-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-PFP ester
  • HY-140976A
    Mal-amido-PEG9-amine TFA 2569576-12-9 99.37%
    Mal-amido-PEG9-amine (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG9-amine TFA
  • HY-141265
    Methyltetrazine-PEG8-acid 2183440-33-5 99.02%
    Methyltetrazine-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-PEG8-acid
  • HY-140035
    Propargyl-PEG24-amine 98.0%
    Propargyl-PEG24-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG24-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG24-amine
PROTAC Linkers Isoform Comparison

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